Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections
نویسندگان
چکیده
Intervention: Patients were randomly assigned to either standard care (n=199) or PCT-guided treatment (n=124). In the latter group, serum PCT concentrations were used to advise clinicians. Use of antibiotics was: strongly discouraged (PCT <0.1 μg/L), discouraged (≥0.1 and <0.25 μg/L), advised (≥0.25 and <0.5 μg/L), or strongly advised (≥0.5 μg/L). Re-evaluation was possible after 6-24 hours in both groups.
منابع مشابه
Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial.
BACKGROUND Lower respiratory tract infections are often treated with antibiotics without evidence of clinically relevant bacterial disease. Serum calcitonin precursor concentrations, including procalcitonin, are raised in bacterial infections. We aimed to assess a procalcitonin-based therapeutic strategy to reduce antibiotic use in lower respiratory tract infections with a new rapid and sensiti...
متن کاملProcalcitonin-Guided Antibiotic Use vs a Standard Approach for Acute Respiratory Tract Infections in Primary Care
Background:Acuterespiratorytract infectionsarethemost common reason for antibiotic therapy in primary care despite their mainly viral etiology. A laboratory test measuring procalcitonin levels in blood specimens was suggested as a tool to reduce unnecessary prescribing of antibiotics. We consider whether antibiotic therapy guided by procalcitoninreduces theuseofantibioticswithout increasingthe ...
متن کامل[Procalcitonin-guided antibiotic use vs. a standard approach for acute respiratory tract infection in primary care].
BACKGROUND Acute respiratory tract infections are the most common reason for antibiotic therapy in primary care despite their mainly viral etiology. A laboratory test measuring procalcitonin levels in blood specimens was suggested as a tool to reduce unnecessary prescribing of antibiotics. We consider whether antibiotic therapy guided by procalcitonin reduces the use of antibiotics without incr...
متن کاملProcalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
There are a number of limitations to using conventional diagnostic markers for patients with clinical suspicion of infection. As a consequence, unnecessary and prolonged exposure to antimicrobial agents adversely affect patient outcomes, while inappropriate antibiotic therapy increases antibiotic resistance. A growing body of evidence supports the use of procalcitonin (PCT) to improve diagnosis...
متن کاملProcalcitonin-guided antibiotic treatment of respiratory tract infections in a primary care setting: are we there yet?
Clinical signs of infection do not allow for correct identification of bacterial and viral aetiology in acute respiratory infections. A valid tool to assist the clinician in identifying patients who will benefit from antibiotic therapy, as well as patients with a potentially serious infection, could greatly improve patient care and limit excessive antibiotic prescriptions. Procalcitonin is a ...
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ورودعنوان ژورنال:
- Critical Care
دوره 9 شماره
صفحات -
تاریخ انتشار 2005